Unraveling self-assembly pathways of the 468-kDa proteolytic machine TET2

Unraveling self-assembly pathways of the 468-kDa proteolytic machine TET2

The spontaneous formation of biological higher-order structures from smaller building blocks, called self-assembly, is a fundamental attribute of life. Although the protein self-assembly is a time-dependent process that occurs at the molecular level, its current understanding originates either from static structures of trapped intermediates or from modeling. Nuclear magnetic resonance (NMR) spe...

SUPPORTING INFORMATION Nonlinear machine learning of patchy colloid self-assembly pathways and mechanisms

Nonlinear machine learning of patchy colloid self-assembly pathways and mechanisms.

Bottom-up self-assembly offers a means to synthesize materials with desirable structural and functional properties that cannot easily be fabricated by other techniques. An improved understanding of the structural pathways and mechanisms by which self-assembling materials spontaneously form from their constituent building blocks is of value in understanding the fundamental principles of assembly...

Nanoparticle self-assembly gated by logical proteolytic triggers.

Geoffrey von Maltzahn,† Todd J. Harris,† Ji-Ho Park,‡ Dal-Hee Min,† Alexander J. Schmidt,† Michael J. Sailor,‡ and Sangeeta N. Bhatia*,†,§,| HarVard-MIT DiVision of Health Sciences and Technology, Cambridge, Massachusetts, Department of Chemistry and Biochemistry, UniVersity of California, San Diego, California, MIT Electrical Engineering and Computer Science, Cambridge, Massachusetts, and Brig...

Supplementary Information Programming Biomolecular Self-Assembly Pathways

ion Catalytic geometry